Hesperidin is a bioflavonoid, a type of plant pigment with antioxidant and anti-inflammatory effects found primarily in citrus fruit. Oranges, grapefruit, lemon, and tangerines all contain hesperidin, which is also available in supplement form. 

Hesperidin is purported to provide a wide range of health benefits, ranging from cancer treatment to hot flash relief. Not all of these benefits are supported by strong scientific research.

Health Benefits

Hesperidin is thought to have beneficial effects on blood vessels. It’s touted as a natural remedy for a number of health problems, including allergies,hemorroids, high blood pressure hot flashes, hay fever, sinusitis, symptoms associated with menopausal changes, premenstrual syndrome and varicose veins. Hesperidin is also said to improve circulation, reduce  inflammation and help fight cancer.

Research on the health effects of hesperidin is fairly limited. However, there’s some evidence that hesperidin may offer certain benefits. Here’s a look at some key study findings.


Diosmin is a flavonoid most commonly found in citrus fruits. Flovanoids are plant compounds that have antioxidant properties, which protect your body from inflammation and unstable molecules called free radicals

Diosmin was first isolated from the figwort plant (Scrophularia nodosa L.) in 1925 and has been used since 1969 as a natural therapy to treat various conditions, such as hemorrhoids, varicose veins, venous insufficiency, leg ulcers, and other circulatory issues

It’s believed to help reduce inflammation and restore normal blood flow in people with venous insufficiency, a condition in which blood flow is impaired

Today, diosmin is widely derived from another flavonoid called hesperidin, which is also found in citrus fruits especially orange rinds

Diosmin is often combined with micronized purified flavonoid fraction (MPFF), a group of flavonoids that includes disomentin, hesperidin, linarin, and isorhoifolin .


Nicotinamide adenine dinucleotide (NAD(+)) is a central metabolic coenzyme/cosubstrate involved in cellular energy metabolism and energy production. It can readily be reduced by two electron equivalents and forms the NADH form, which is the minority species to NAD(+) under most physiologic conditions.

NAD+ is essential to the creation of energy in the body and the regulation of pivotal cellular processes. … NAD+ has two general sets of reactions in the human body: helping turn nutrients into energy as a key player in metabolism and working as a helper molecule for proteins that regulate other cellular functions.